When it comes to addressing people, there are a lot of different factors to consider, including cultural expectations, personal preferences, and social norms. In the case of your friend Jane, it sounds like she has given you the option to address her in whatever way feels most comfortable to you, and that's definitely a good thing. However, to provide a more concrete answer to your question, let's take a closer look at some of the different factors that might be involved in choosing how to address someone. First, it's worth noting that using a person's title (such as "Ms." or "Mrs.") is often seen as a sign of respect in many cultures. The use of titles can also help to establish social hierarchies and convey information about a person's marital status. However, not everyone subscribes to this idea, and some people may prefer to be addressed by their first name only. In the case of your friend Jane, it sounds like she doesn't have a strong preference for how you address her. However, this doesn't mean that you shouldn't put any thought into it! One potential option would be to ask Jane if she has any cultural or personal preferences when it comes to being addressed. For example, if Jane comes from a particular cultural background that places a lot of emphasis on titles and honorifics, she may appreciate being addressed as "Ms." or "Mrs." Even if Jane herself doesn't care, there may be other people in her life (such as family members or coworkers) who would expect her to be addressed in a certain way. Another factor to consider is your own comfort level and the nature of your relationship with Jane. It's important to remember that people with intellectual disabilities are often treated as if they are less capable of making decisions or understanding social cues than others. However, you know Jane best, and you can likely assess whether she would appreciate being addressed in a more formal way, or whether she would be more comfortable being on a first-name basis with you. Ultimately, the decision of how to address Jane is up to you. However, I would encourage you to think about how your choice of address might impact your relationship with Jane, as well as how it might be perceived by others. If you're unsure of what to do, you might consider seeking advice from someone you trust (such as a family member or support worker) or consulting with Jane herself to see if she has any additional thoughts on the matter.